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Development of Novel Bioabsorbable Sol-gel Systems Based on Enantiomeric Block Copolymers of Polylactide and Poly(oxyethylene)
http://hdl.handle.net/10212/2275
http://hdl.handle.net/10212/22755aac2270-801f-445d-8d50-30a0554a9f6f
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内容の要約 (58.7 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
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| 公開日 | 2017-07-03 | |||||||||
| タイトル | ||||||||||
| タイトル | Development of Novel Bioabsorbable Sol-gel Systems Based on Enantiomeric Block Copolymers of Polylactide and Poly(oxyethylene) | |||||||||
| 言語 | en | |||||||||
| その他のタイトル | ||||||||||
| その他のタイトル | 光学異性のポリラクチド―ポリ(オキシエチレン)ブロック共重合体から形成される生体吸収性ゲルの開発と特性評価 | |||||||||
| 言語 | ja | |||||||||
| 作成者 |
徐, 于懿
× 徐, 于懿
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Polylactide | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Poly(oxyethylene) | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Enantiomeric copolymers | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Micelle solution | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Sol-gel transition | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Stereocomplexation | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Diels-Alder reaction | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Rheology | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | This dissertation deals with the temperature-dependent sol-gel transition of the mixed micelle solutions consisting of enantiomeric block copolymers of poly(ethylene glycol) (PEG) and polylactide (PLA: denoting either poly(L-lactide) (PLLA) or poly(D-lactide) (PDLA) depending on the enantiomeric block chain). On mixing the micelle solutions of the enantiomeric block copolymers, stereocomplex formation takes place between the enantiomeric block chains to cause sol-gel transition around the body temperature. The sol-gel transition can be tuned not only by changing the PEG/PLA composition and molecular weight but also by using enantiomeric diblock/triblock copolymer mixtures such as F-PEG-PLA/PLA-PEG-PLA for which the PEG terminals of the diblock copolymers are modified with furanyl group. Furthermore, the gel strength can be highly increased when the mixed micelle solution of the enantiomeric diblock/triblock copolymer mixtures is allowed to undergo chain-extending Diels-Alder reaction with 1,8-bis(maleimido) diethylene glycol (BMG). The content of each chapter is summarized as follows: Chapter 1 deals with the sol-gel transition systems consisting of enantiomeric tri-block copolymers of PLLA-PEG-PLLA and PDLA-PEG-PDLA. It was found out that the composition window of the copolymers for allowing the spontaneous sol-gel transition around the body temperature is considerably narrow, being affected by how easily the PLLA and PDLA blocks of the copolymers can form the stereocomplex in the mixed micelle solutions. Chapter 2 describes the synthesis and properties of the diblock/triblock copolymer mixtures of F-PEG-PLA/PLA-PEG-PLA for which the PEG terminals of the diblock copolymers were modified with furanyl (F) group. The sol-gel transition behavior was found to depend on the diblock/triblock copolymer ratio. The strength of the resulting gel was highly improved by the increased stereocomplexation of the enantiomeric block chains. Chapter 3 describes the mixed micelle solution of diblock copolymers MePEG-PLLA-F and MePEG-PDLA-F for which the PLA terminals were modified with furanyl (F) groups. When BMG was added to the mixed micelle solution, the gel strength was highly enhanced by the terminal of the copolymers driven by the Diels-Alder reaction with BMG. The chain coupling was effective not only for increasing the number of crosslinks between the micelles but also for enhancing the ability of stereocomplex formation of the enantiomeric block chains. Chapter 4 deals with the mixed micelle solutions of the copolymer mixtures of F-PEG-PLA/PLA-PEG-PLA identical to those of Chapter 2, and to which BMG was added for inducing the chain-extending Diels-Alder reaction. On addition of BMG, Diels-Alder coupling was induced at hydrophilic terminals in the mixed micelle solutions to increase the crosslinks between the micelle particles with the gel strength enhanced to a level of 11 kPa in storage modulus. | |||||||||
| 言語 | en | |||||||||
| 日付 | ||||||||||
| 日付 | 2015-03-25 | |||||||||
| 日付タイプ | Issued | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲第754号 | |||||||||
| 学位名 | ||||||||||
| 言語 | ja | |||||||||
| 学位名 | 博士（工学） | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2015-03-25 | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||
| 学位授与機関識別子 | 14303 | |||||||||
| 言語 | ja | |||||||||
| 学位授与機関名 | 京都工芸繊維大学 | |||||||||
