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Silicon Nitride: A Unique Bioceramic for Total Joint Arthroplasty
http://hdl.handle.net/10212/2300
http://hdl.handle.net/10212/23009b632171-33e9-4dbf-a647-4824dc80535b
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内容の要約 (13.4 KB)
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内容・審査結果の要旨 (354.3 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
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| 公開日 | 2017-07-04 | |||||||||
| タイトル | ||||||||||
| タイトル | Silicon Nitride: A Unique Bioceramic for Total Joint Arthroplasty | |||||||||
| 言語 | en | |||||||||
| その他のタイトル | ||||||||||
| その他のタイトル | 窒化ケイ素：人工関節置換術における特異的生体機能セラミックス | |||||||||
| 言語 | ja | |||||||||
| 作成者 |
マッキンタイア, ブライアン ジェイ
× マッキンタイア, ブライアン ジェイ
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | silicon nitride | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | bioceramic | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | orthopaedic | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | arthroplasty | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | hip | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | knee | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | bearing | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | bioinert | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Raman spectroscopy | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | cathodoluminescence spectroscopy | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | wear | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | polyethylene | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Advanced bioceramics currently play important curative roles for various orthopaedic morbidities, including their use as bearing surfaces in total hip arthroplasty (THA). Introduced during the latter half of the 20th century, these materials rapidly evolved from monolithic alumina (Al2O3) and yttria-stabilized zirconia (Y-TZP) to alumina-zirconia composites (ZTA). While their use in THA has proliferated because of their perceived bioinertness, they have yet to deliver the promised objective of being “lifetime” devices; which, in fact, brings into question the very definition of bioinertness. However, only recently have investigative tools been developed which allow examination of the surface chemistry and mechanical properties of these materials at the molecular level. In this thesis, Raman and cathodoluminescence spectroscopy coupled with traditional micromechanical methods were employed to evaluate the surface chemistry and fracture toughness of three bioceramics: Al2O3, ZTA, and a promising alternative non-oxide material, silicon nitride (Si3N4). Contrary to conventional wisdom, oxide-based ceramics were not bioinert. Indeed, bio-tribological interactions resulted in the release of oxygen from Al2O3, and mechanical instability in ZTA, which in turn, may accelerate oxidative degradation in polyethylene and increased wear of self-mated bearings, respectively. On the other hand, Si3N4 was also not bioinert; but uniquely, it possesses positive non-bioinertness. It scavenges oxygen from the tribolayer instead of releasing it, thereby providing a protective benefit to polyethylene; and its surface toughness is immune to even severe hydrothermal conditions. Nevertheless, wear studies using self-mated Si3N4 bearings exhibited fluctuating friction (i.e., slip-stick behavior), which was also attributable to chemical interactions with the biologic environment. Overcoming this limitation represents a key challenge and recommendation for this novel biomaterial. Lastly, it was also discovered that Si3N4’s tribochemical wear products (i.e., predominately silicic acid, Si(OH)4, and ammonia, NH3) are soluble, resorbable, and can potentially buffer the local pH within the joint capsule. As such, Si3N4 may yet prove to be beneficial for arthritic patients whose diseased joints have degeneratively low pH values. While additional research is required, particularly to overcome the unfavorable frictional behavior for self-mated bearings, Si3N4’s performance as an articulation device appears particularly promising. | |||||||||
| 言語 | en | |||||||||
| 日付 | ||||||||||
| 日付 | 2015-09-24 | |||||||||
| 日付タイプ | Issued | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 乙第198号 | |||||||||
| 学位名 | ||||||||||
| 言語 | ja | |||||||||
| 学位名 | 博士（工学） | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2015-09-24 | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||
| 学位授与機関識別子 | 14303 | |||||||||
| 言語 | ja | |||||||||
| 学位授与機関名 | 京都工芸繊維大学 | |||||||||
