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ADVANCED SPECTROSCOPIC METHODS FOR THE QUANTITATIVE ANALYSIS OF SYNTHETIC BIOMATERIALS AND BIOGENIC TISSUE
http://hdl.handle.net/10212/2307
http://hdl.handle.net/10212/23079b472f16-2636-4674-a1d9-8db0578c4471
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全文 (43.7 MB)
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内容・審査結果の要旨 (317.0 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
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| 公開日 | 2017-09-01 | |||||||||
| タイトル | ||||||||||
| タイトル | ADVANCED SPECTROSCOPIC METHODS FOR THE QUANTITATIVE ANALYSIS OF SYNTHETIC BIOMATERIALS AND BIOGENIC TISSUE | |||||||||
| 言語 | en | |||||||||
| その他のタイトル | ||||||||||
| その他のタイトル | 合成生体材料および生物起源物質の定量分析のための先進的分光理論 | |||||||||
| 言語 | ja | |||||||||
| 作成者 |
ボッフェッリッ, マルコ
× ボッフェッリッ, マルコ
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Biomaterials | |||||||||
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| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Zirconia | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Zirconia toughened Alumina | |||||||||
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| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Hydroxyapatite | |||||||||
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| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Human Skin | |||||||||
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| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Raman Spectroscopy | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Cathodoluminescence | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | This doctoral thesis is aimed at describing new developments of Raman spectroscopy in the field of biomedical science, specifically oriented in the study of synthetic man-made biomaterials and natural biogenic materials. In this work, it will be highlighted the high versatility of Confocal Raman microprobe spectroscopy in a number of different inorganic and organic sample as a demonstration of newly developed computational algorithms, also when combined with different spectroscopic analyses such as Cathodoluminescence and X-Ray diffraction. A spectroscopic study on the importance of oxygen vacancy in a synthetic biomaterial as zirconia will show the feasibility of the mentioned techniques in detecting polymorphic transformation. This will be directly applied to the analyses of artificial hip joints, where materials degradation during in-vitro testing or during in-vivo service could be observable. Application of Raman techniques will also be shown with the purpose of a reliable screening of human biogenic materials like as teeth and skin, in which their composite structures are made of combinations of different molecules. In particular, new Raman algorithms have been developed for practical dental research and forensic analyses. The Raman tensor element method has quantitatively been applied to the analysis of local crystallographic orientation in both single-crystal hydroxyapatite and human teeth to look into the efficacy of vibrational assessments in locating chemical and crystallographic fingerprints of dental caries and non-cavitated carious lesions. Clear spectroscopic features could directly be translated in terms of a rigorous and quantitative classification of crystallographic and chemical characteristics of diseased enamel structures. Finally, the Raman microprobe spectrometry has been applied to study the biophysical links between vibrational characteristics and the chemical changes associated with aging in human skin. Our spectroscopic approach yields clear compositional information of protein folding and crystallization of lipid structures, which can lead to a precise identification of age from infants to adults. | |||||||||
| 言語 | en | |||||||||
| 日付 | ||||||||||
| 日付 | 2016-03-25 | |||||||||
| 日付タイプ | Issued | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲第781号 | |||||||||
| 学位名 | ||||||||||
| 言語 | ja | |||||||||
| 学位名 | 博士（工学） | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2016-03-25 | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||
| 学位授与機関識別子 | 14303 | |||||||||
| 言語 | ja | |||||||||
| 学位授与機関名 | 京都工芸繊維大学 | |||||||||
