{"created":"2025-09-08T01:55:52.842667+00:00","id":2000361,"links":{},"metadata":{"_buckets":{"deposit":"c230aa77-dc39-4213-a160-7dd5d4302ac6"},"_deposit":{"created_by":13,"id":"2000361","owners":[13],"pid":{"revision_id":0,"type":"depid","value":"2000361"},"status":"published"},"_oai":{"id":"oai:kit.repo.nii.ac.jp:02000361","sets":["1753926516427:1753929991454:1753935963586"]},"author_link":[],"item_30002_access_rights4":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_30002_alternative_title1":{"attribute_name":"Alternative Title","attribute_value_mlt":[{"subitem_alternative_title":"ショウジョウバエlipid storage droplet-1および 2遺伝子の発生過程における機能","subitem_alternative_title_language":"ja"}]},"item_30002_creator2":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorAlternatives":[{"creatorAlternative":"チャン ドゥイ ビン","creatorAlternativeLang":"ja"}],"creatorNames":[{"creatorName":"TRAN DUY BINH","creatorNameLang":"en"}]}]},"item_30002_date11":{"attribute_name":"Date","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-09-25","subitem_date_issued_type":"Issued"}]},"item_30002_date_granted32":{"attribute_name":"Date Granted","attribute_value_mlt":[{"subitem_dategranted":"2019-09-25"}]},"item_30002_degree_grantor33":{"attribute_name":"Degree Grantor","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"京都工芸繊維大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14303","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_30002_degree_name31":{"attribute_name":"Degree Name","attribute_value_mlt":[{"subitem_degreename":"博士（学術）","subitem_degreename_language":"ja"}]},"item_30002_description9":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Lipid droplets comprise neutral lipids that are enclosed by a monolayer of phospholipids. The surface of a lipid droplet is decorated with several types of proteins such as structural proteins, lipid-synthesis enzymes, lipases, and membrane-trafficking proteins. Notably, Drosophila and mammals share these lipid metabolism-related genes and basic metabolism function. Perilipins are known to be involved in regulating the accessibility of lipases; e.g., mammalian adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL), by either recruiting these enzymes or preventing their access to lipid droplets. Perilipins regulate ATGL activation through the interaction with comparative gene identification 58 (CGI-58), which is an ATGL coactivator. Also, the role of perilipin 1 locus was identified as obesity risk factors, and perilipin 2 participates in the pathogenesis of diet-induced insulin resistance. Drosophila encodes two perilipin family member, Lsd-1/perilipin-1 and Lsd-2/perilipin-2. LSD-1 indiscriminately labels lipid droplets of varying size whereas LSD-2 localizes to smaller lipid droplets. LSD-1 exclusively locates on lipid droplets while LSD-2 presents both in the cytoplasm and on lipid droplets. However, the roles of these genes in development remain unclear. This present study, we found that LSD-1 expresses not only in wing pouch but also detection in notum of wing imaginal disc. Specific knockdown of Lsd-1 by pannir-GAL4 driver in wing disc leads to split thorax phenotype, suggesting that an essential role of Lsd-1 in development of Drosophila thorax. This role of Lsd-1 is dependent on the activity of the Drosophila c-Jun N-terminal kinase, as overexpression of basket suppresses split thorax induced by Lsd-1 knockdown. Besides these events, depletion of Lsd-1 causes an enhancement apoptosis cell death in wing notum. Moreover, we also demonstrated that knockdown of Lsd-2 led to dramatic cell death and developmental defects in the wing blade. Also, Lsd-2 knockdown-induced apoptosis cell death was shown to be mediated by dFoxO. Taken together, these data indicate Lsd-1 and Lsd-2 have main role in Drosophila development.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_30002_dissertation_number30":{"attribute_name":"Dissertation Number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第933号"}]},"item_30002_file35":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","displaytype":"detail","filename":"D1-0933_y1.pdf","filesize":[{"value":"42.2 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"内容の要約","objectType":"summary","url":"https://kit.repo.nii.ac.jp/record/2000361/files/D1-0933_y1.pdf"},"version_id":"a608264f-fc55-43ca-afb7-fa94f29a6487"},{"accessrole":"open_access","displaytype":"detail","filename":"D1-0933.pdf","filesize":[{"value":"178.5 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"内容・審査結果の要旨","objectType":"abstract","url":"https://kit.repo.nii.ac.jp/record/2000361/files/D1-0933.pdf"},"version_id":"0efb29ac-7994-453b-84e9-8e7b6b950f7f"}]},"item_30002_language12":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_30002_resource_type13":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_30002_subject8":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Drosophila","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipid storage droplet-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipid storage droplet-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Development","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Development","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dFoxO","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"JNK signaling pathway","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LSD-1 may positively control JNK signaling pathway","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"which is required for thorax development","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Role of LSD-2 in the development of Drosophila wings via genetically interaction with dFoxO","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30002_title0":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Function of lipid storage droplet-1 and 2 in development of Drosophila melanogaster","subitem_title_language":"en"}]},"item_title":"Function of lipid storage droplet-1 and 2 in development of Drosophila melanogaster","item_type_id":"40002","owner":"13","path":["1753935963586"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-20"},"publish_date":"2022-04-20","publish_status":"0","recid":"2000361","relation_version_is_last":true,"title":["Function of lipid storage droplet-1 and 2 in development of Drosophila melanogaster"],"weko_creator_id":"13","weko_shared_id":-1},"updated":"2026-01-21T05:28:20.234536+00:00"}